Donergest 10 is indicated for the management of menstrual irregularities, secondary amenorrhoea, dysmenorrhoea, endometriosis, and luteal phase insufficiency. It is also used as part of hormone replacement therapy (HRT) and to support pregnancy in women experiencing threatened or recurrent miscarriage due to progesterone deficiency.

MECHANISM OF ACTION:
Dydrogesterone acts on the endometrium (lining of the uterus) to restore normal secretory transformation, helping regulate menstrual bleeding and promoting a healthy uterine environment. Unlike some other progestogens, dydrogesterone has no androgenic, estrogenic, or glucocorticoid effects, making it well tolerated and physiologically selective for progesterone receptors.

USES:

• Regulation of menstrual cycle disorders (irregular or painful periods)
• Treatment of endometriosis
• Management of secondary amenorrhoea
• Treatment of premenstrual syndrome (PMS)
• Support of early pregnancy and prevention of miscarriage due to progesterone deficiency
• Adjunct therapy with estrogen in hormone replacement therapy (HRT)

MEDICINAL BENEFITS:

• Restores hormonal balance in women with progesterone deficiency
• Regulates normal menstrual flow and relieves menstrual pain
• Helps manage endometrial growth in endometriosis
• Supports implantation and pregnancy maintenance
• Well tolerated with minimal hormonal side effects

DOSAGE & ADMINISTRATION:
Dosage and duration of therapy should be individualized based on the indication and clinical response. The usual adult dose is one tablet (10 mg) once or twice daily, or as directed by the physician. Swallow the tablet whole with a glass of water, with or without food. Continue treatment as advised by your healthcare provider.

STORAGE:
Store in a cool, dry place below 25°C. Protect from light and moisture. Keep out of reach of children.

CONTRAINDICATIONS:

• Hypersensitivity to Dydrogesterone or any excipients in the formulation
• Known or suspected hormone-dependent malignancy
• Undiagnosed vaginal bleeding
• Severe liver disease or hepatic dysfunction

WARNINGS & PRECAUTIONS:

• Use with caution in patients with a history of liver disorders or depression
• Regular medical supervision is recommended during prolonged therapy
• Should not be used for contraception
• Use in pregnancy and lactation only under medical supervision

SIDE EFFECTS:
Most patients tolerate Dydrogesterone well. Occasionally, mild side effects such as headache, breast tenderness, nausea, abdominal discomfort, or mood changes may occur. These are generally mild and transient. Consult your doctor if any side effects persist.

DISCLAIMER:
Donergest 10 should be used strictly under medical supervision. The dosage and duration should be as directed by a qualified healthcare professional based on the patient’s medical condition.

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Levocetirizine is a second-generation antihistamine that works by blocking the action of histamine, a natural substance responsible for causing allergic symptoms. It provides long-lasting relief from nasal and non-nasal allergy symptoms with minimal drowsiness.

Montelukast is a leukotriene receptor antagonist that works by blocking the effects of leukotrienes, inflammatory chemicals released during allergic reactions. It helps reduce inflammation in the airways, relieves nasal congestion, and prevents asthma symptoms triggered by allergens or exercise.

Together, these two agents provide comprehensive control of both upper and lower respiratory allergic symptoms, improving overall quality of life and respiratory comfort.

USES:

• Management of allergic rhinitis (seasonal and perennial)
• Relief from nasal congestion, sneezing, and itchy/watery eyes
• Supportive therapy in asthma and exercise-induced bronchospasm
• Treatment of chronic allergic conditions affecting the nose, throat, and airways

MEDICINAL BENEFITS:

• Provides dual action — antihistaminic and anti-inflammatory
• Offers effective and long-lasting relief from allergic symptoms
• Helps prevent asthma attacks associated with allergies
• Minimizes the need for additional medications in combined allergic and respiratory conditions
• Well-tolerated with minimal side effects

DOSAGE & ADMINISTRATION:
Dosage should be directed by the physician based on the patient’s condition. The usual adult dose is one tablet once daily, preferably in the evening with or without food. Swallow the tablet whole with water. Do not crush or chew. Continue medication as advised by your doctor.

STORAGE:
Store in a cool, dry place below 25°C. Protect from moisture and direct sunlight. Keep out of reach of children.

CONTRAINDICATIONS:

• Hypersensitivity to Levocetirizine, Montelukast, or any component of the formulation
• Severe hepatic impairment
• Patients with galactose intolerance or lactase deficiency (if applicable excipients present)

WARNINGS & PRECAUTIONS:

• Use with caution in patients with kidney or liver impairment
• Avoid alcohol consumption while taking this medicine, as it may enhance drowsiness
• Report any unusual mood or behavioral changes (rare with Montelukast)
• Use during pregnancy or lactation only under medical advice

SIDE EFFECTS:
Common side effects may include mild drowsiness, headache, dry mouth, abdominal pain, or fatigue. These are usually temporary and resolve with continued use. Rarely, mood changes or sleep disturbances may occur. Consult your doctor if symptoms persist or worsen.

DISCLAIMER:
Least M should be used under the supervision of a registered medical practitioner. Do not exceed the recommended dose without medical advice.

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Type 2 diabetes mellitus is a chronic, progressive condition characterized by insulin resistance and impaired insulin secretion, leading to persistent hyperglycaemia. Effective glycaemic control is essential to prevent or delay diabetes-related complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disease.

Linatab D 5/10 combines two agents with complementary mechanisms of action:

• Linagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor, increases the levels of incretin hormones (GLP-1 and GIP), which enhance insulin secretion and suppress glucagon release in a glucose-dependent manner.
• Dapagliflozin, a Sodium-Glucose Cotransporter-2 (SGLT2) inhibitor, reduces blood glucose by promoting urinary glucose excretion through inhibition of renal glucose reabsorption.

Together, these agents improve glycaemic control through both insulin-dependent and insulin-independent pathways, providing better fasting and postprandial blood glucose management with additional benefits such as weight reduction and blood pressure improvement.

USES:

• Management of Type 2 Diabetes Mellitus in adults
• As an adjunct to diet and exercise for improved glycaemic control
• May be used as combination therapy when monotherapy with either component is insufficient

MEDICINAL BENEFITS:

• Dual mechanism for optimal glycaemic control
• Promotes mild weight loss and blood pressure reduction
• Low risk of hypoglycaemia when used as directed
• Provides cardiovascular and renal protection benefits associated with Dapagliflozin
• Improves beta-cell function and insulin sensitivity

DOSAGE & ADMINISTRATION:
Dosage should be individualized based on patient needs and clinical response. The usual recommended dose is one tablet once daily, taken with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew. Continue therapy as directed by your physician.

STORAGE:
Store in a cool, dry place below 25°C. Protect from moisture and direct sunlight. Keep out of reach of children.

CONTRAINDICATIONS:

• Hypersensitivity to Linagliptin, Dapagliflozin, or any excipients
• Severe renal impairment (eGFR < 30 mL/min/1.73 m²) or patients on dialysis
• Type 1 diabetes mellitus or diabetic ketoacidosis
• History of serious hypersensitivity reactions (e.g., angioedema) to DPP-4 inhibitors

WARNINGS & PRECAUTIONS:

• Use with cautions
• Maintain adequate hydration to prevent dehydration and hypotension
• Monitor for signs of urinary tract infections or genital mycotic infections
• Temporarily discontinue before surgery or during acute illness to avoid ketoacidosis risk
• Avoid excessive alcohol intake during therapy
• Use in pregnancy or lactation only under medical supervision

SIDE EFFECTS:
Common side effects may include increased urination, mild urinary tract infection, genital fungal infection, headache, nasopharyngitis, or mild hypoglycaemia (especially if used with other antidiabetic agents). Most effects are transient and mild. Consult your doctor if any side effects persist or worsen.

DISCLAIMER:
Linatab D 5/10 should be used only under the supervision of a qualified healthcare professional. Dosage and duration must be based on medical advice, patient response, and blood glucose monitoring.

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Type 2 diabetes mellitus is a chronic metabolic disorder characterized by insulin resistance and insufficient insulin secretion, leading to elevated blood glucose levels. Proper glycaemic control helps prevent long-term complications such as neuropathy, nephropathy, retinopathy, and cardiovascular diseases.

Linatab MOD 5/500 SR combines two complementary agents that work synergistically:

• Linagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor, increases the levels of incretin hormones, which enhance insulin secretion and suppress glucagon release after meals, helping maintain glucose control.
• Metformin SR, a biguanide, reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity in peripheral tissues. Its sustained-release formulation ensures a gradual and prolonged therapeutic effect with improved gastrointestinal tolerance.

Together, these components effectively reduce both fasting and postprandial blood glucose levels, providing stable and long-term glycaemic control.

USES:

• Management of Type 2 Diabetes Mellitus in adults
• As an adjunct to diet and exercise to improve blood glucose control
• May be used as dual therapy when monotherapy with metformin or linagliptin alone is insufficient

MEDICINAL BENEFITS:

• Provides a dual mechanism of action for effective glycaemic control
• Low risk of hypoglycaemia when used as directed
• Improves insulin sensitivity and enhances endogenous insulin release
• Sustained-release formulation offers better gastrointestinal tolerance and once-daily convenience
• May support weight stability or modest reduction

DOSAGE & ADMINISTRATION:
Dosage should be individualized based on patient response and tolerance. The usual recommended dose is one tablet once daily, taken with meals to minimize gastrointestinal discomfort. Swallow the tablet whole with water. Do not crush or chew. Continue therapy as advised by the physician.

STORAGE:
Store in a cool, dry place below 25°C. Protect from direct sunlight and moisture. Keep out of reach of children.

CONTRAINDICATIONS:

• Known hypersensitivity to Linagliptin, Metformin, or any component of the formulation
• Severe renal impairment or end-stage renal disease (eGFR < 30 mL/min/1.73 m²)
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis
• Conditions associated with hypoxia (e.g., heart failure, respiratory failure, myocardial infarction)

WARNINGS & PRECAUTIONS:

• Use with caution in patients with renal or hepatic impairment
• Avoid excessive alcohol consumption to reduce the risk of lactic acidosis
• Temporarily discontinue before major surgery or radiologic procedures involving iodinated contrast
• Monitor renal function and blood glucose regularly during therapy
• Use during pregnancy or lactation only under medical supervision

SIDE EFFECTS:
Common side effects may include mild gastrointestinal discomfort such as nausea, diarrhoea, or abdominal pain, especially during initial therapy. Rarely, hypoglycaemia, headache, or upper respiratory tract infection may occur. Most effects are mild and resolve with continued use.

DISCLAIMER:
Linatab MOD 5/500 SR should be used strictly under medical supervision. Dosage and duration should be based on individual clinical assessment and blood glucose monitoring.

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Cholecalciferol is synthesized naturally in the skin upon exposure to sunlight, but inadequate sun exposure, dietary insufficiency, or certain health conditions can lead to Vitamin D deficiency. DonorD3 60K is formulated to correct and prevent Vitamin D deficiency and related conditions such as osteomalacia, rickets, osteoporosis, and hypocalcaemia. It also plays a vital role in maintaining immune system function, muscle strength, and overall well-being.

USES:

• Treatment and prevention of Vitamin D₃ deficiency
• Supports bone health and calcium absorption
• Helps manage conditions such as osteoporosis and osteomalacia
• Strengthens immunity and improves muscle performance
• Beneficial in individuals with limited sunlight exposure

MEDICINAL BENEFITS:
DonorD3 60K helps maintain optimal Vitamin D levels in the body, ensuring proper calcium absorption and bone mineralization. It supports overall musculoskeletal health, reduces the risk of fractures, and enhances immune response. Regular supplementation helps correct Vitamin D deficiency, which is common in adults due to sedentary lifestyle or inadequate sunlight exposure.

DOSAGE & ADMINISTRATION:
Dosage should be directed by the physician based on individual requirements and serum Vitamin D levels. Commonly, one capsule of DonorD3 60K is taken once weekly or as advised by the healthcare professional. Swallow the capsule whole with water; do not chew or break.

STORAGE:
Store in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children.

CONTRAINDICATIONS:

• Known hypersensitivity to Cholecalciferol or any excipients
• Hypercalcaemia or hypervitaminosis D
• Severe renal impairment or nephrolithiasis (kidney stones)

WARNINGS & PRECAUTIONS:
Use cautiously in patients with kidney or liver disease. Regular monitoring of serum calcium and Vitamin D levels is advised during prolonged therapy. Avoid excessive intake to prevent Vitamin D toxicity. Pregnant or lactating women should use under medical supervision only.

SIDE EFFECTS:
When taken in recommended doses, DonorD3 60K is generally well tolerated. Rarely, excessive intake may cause nausea, vomiting, constipation, weakness, or hypercalcaemia. Consult your physician if any unusual symptoms occur.

DISCLAIMER:
DonorD3 60K should be used strictly as advised by a registered medical practitioner. Do not exceed the recommended dose without medical consultation.

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Type 2 diabetes mellitus is a chronic metabolic disorder in which the body either does not produce enough insulin or cannot effectively utilize it (insulin resistance). Uncontrolled blood sugar levels over time can lead to serious complications such as neuropathy, nephropathy, retinopathy, and cardiovascular diseases.

Linatab E 5/25 combines two complementary mechanisms of action. Linagliptin is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor that works by increasing incretin hormone levels, which help regulate blood glucose by stimulating insulin secretion and suppressing glucagon release after meals. Empagliflozin is a Sodium-Glucose Cotransporter-2 (SGLT2) inhibitor that lowers blood glucose levels by promoting glucose excretion through urine. It also offers additional cardiovascular and renal benefits in patients with type 2 diabetes. Together, these agents effectively reduce both fasting and postprandial blood glucose levels, improve glycaemic control, and support weight and blood pressure reduction.

USES:
For the treatment of Type 2 Diabetes Mellitus in adults. As an adjunct to diet and exercise to improve glycaemic control. May be used as dual therapy or in combination with other antidiabetic agents (e.g., metformin or insulin) as prescribed by a healthcare professional.

MEDICINAL BENEFITS:
Provides a dual mechanism of glucose reduction through both insulin-dependent and insulin-independent pathways. Helps maintain better overall glycaemic control throughout the day. May promote weight reduction and lower systolic blood pressure. Has a low risk of hypoglycaemia when used as monotherapy or with metformin. Demonstrated cardiovascular and renal protection benefits with empagliflozin.

DOSAGE & ADMINISTRATION:
Dosage should be individualized based on the patient’s condition and response. The usual recommended dose is one tablet once daily, taken in the morning with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew. Continue therapy as directed by your physician and do not discontinue without medical advice.

STORAGE:
Store in a cool, dry place below 25°C. Protect from light and moisture. Keep out of reach of children.

WARNINGS & PRECAUTIONS:
Use cautiously. Maintain adequate hydration to prevent dehydration due to increased urination. Monitor for symptoms of urinary tract or genital mycotic infections. Temporarily discontinue before major surgery or in cases of acute illness with reduced food or fluid intake. Avoid alcohol consumption. Use during pregnancy and breastfeeding only if clearly needed and under medical supervision.

SIDE EFFECTS:
Common side effects may include increased urination, urinary tract infection, genital fungal infection, thirst, dehydration, mild hypotension, nasopharyngitis, upper respiratory tract infection, headache, or joint pain. Most effects are mild and resolve on their own. Consult your doctor if any symptoms persist or become bothersome.

DISCLAIMER:
Linatab E 5/25 should be taken strictly under medical supervision. Dosage and duration must be individualized based on blood glucose response and clinical judgement.

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PESRY 3D comprises two medicines, namely: ‘Clindamycin’ (antibiotic) and ‘Clotrimazole’ (antifungal). Clindamycin belongs to the lincomycin antibiotic group that works by inhibiting bacterial protein synthesis, required for the survival of bacteria. As a result, it inhibits bacterial growth but does not kill them (bacteriostatic effect). On the other hand, Clotrimazole belongs to the imidazole antifungal group that kills fungi by causing holes in its cell membrane, thereby leaking all content out.

Use PESRY 3D as suggested by your doctor. Common side effects of CLINDAMYCIN + CLOTRIMAZOLE include a burning sensation, irritation, and itching. These side effects may not occur in every patient using this medication and differ individually. If the side effects persist longer or worsen, please seek a doctor’s advice.

Inform your doctor if you are allergic to CLINDAMYCIN+CLOTRIMAZOLE or any of its components. Let your doctor know if you have any liver, kidney, and gastrointestinal diseases (diarrhea and colitis, inflammation of the colon), allergic conditions (asthma, hay fever, and eczema), diabetes, and immune system problems (HIV-AIDS). Clotrimazole in CLINDAMYCIN+CLOTRIMAZOLE may weaken the activities of rubber products, such as contraceptive devices, latex condoms, diaphragms, and cervical caps. Pregnant and breastfeeding women should consult a doctor before using CLINDAMYCIN+CLOTRIMAZOLE.

Uses of PESRY 3D

Vaginal infections.

Medicinal Benefits
PESRY 3D is used to treat vaginal infections like bacterial vaginosis (BV), candidiasis, and trichomoniasis. It comprises two medicines: ‘Clindamycin’ (antibiotic) and ‘Clotrimazole’ (antifungal). Clindamycin is an antibiotic drug that works by inhibiting bacterial protein synthesis, inhibiting bacterial growth. It shows a bacteriostatic effect, stopping bacterial reproduction. Clotrimazole is an imidazole antifungal medication that stops the growth of fungi by causing damage and leakage to the fungal cell membrane. Together, CLINDAMYCIN+CLOTRIMAZOLE treats vaginal infections caused by bacteria, yeast, and parasites, preventing white discharge, itchiness, and inflammation in the genitourinary area.

Directions for Use

Vaginal Capsule/Suppository/Gel: Take the medicine and place it on the applicator. Lie relaxed on your back. Gently insert the applicator tip into the vagina and push the plunger to release the gel/capsule/suppository into the vagina. If you are inserting without an applicator, place the gel/capsule/suppository on your clean finger and gently insert it into the vagina. Vaginal Wash: Take the advised amount of vaginal wash and massage gently on the vaginal area to produce lather. Rinse off with clean water.

Storage

Store in a cool and dry place away from sunlight.

Side Effects of CLINDAMYCIN+CLOTRIMAZOLE

Burning sensation
Irritation
Itching

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CLEARGET belongs to the class of hormone replacement therapy medicines used in menopausal women without a hysterectomy (surgery to remove the uterus). PROGESTERONE (NATURAL MICRONIZED) is employed to manage menstruation in women of childbearing age who have stopped having periods but have not reached menopause. Additionally, it is utilized in the treatment of endometrial hyperplasia and female infertility.

CLEARGEST contains Natural Micronized Progesterone, a female hormone that plays a crucial role in regulating ovulation and menstruation. PROGESTERONE (NATURAL MICRONIZED) induces secretory changes in the endometrium lining of the uterus, promotes breast development, relaxes the uterus, inhibits follicle maturation and release, and supports the maintenance of pregnancy.

Avoid taking PROGESTERONE (NATURAL MICRONIZED) if you are allergic to it. Inform your doctor about any history of heart attack, stroke, blood clots, or breast cancer, as this medication may increase the risk of these conditions. Notify your doctor if you are pregnant or breastfeeding before initiating PROGESTERONE (NATURAL MICRONIZED). Be cautious of potential dizziness and drowsiness associated with this medicine, and refrain from activities requiring concentration, such as driving. Keep your doctor updated on your health status and disclose all current and previous medications to assess potential interactions. Consumption of alcohol should be avoided, as it may intensify dizziness and drowsiness.
Uses of CLEARGEST (NATURAL MICRONIZED PROGESTERONE)

Hormone replacement therapy, Female Infertility, Endometrial hyperplasia, Amenorrhea

Medicinal Benefits

Natural micronized progesterone is a hormone replacement treatment prescribed for menopausal women without a history of hysterectomy. It facilitates the initiation of menstrual cycles in women approaching menopause, who have ceased menstruation. Additionally, it is employed to prevent uterine overgrowth in postmenopausal women undergoing estrogen hormone replacement therapy (HRT). This medication, containing progesterone, plays a crucial role in regulating ovulation and menstruation. Its functions include inducing secretory changes in the uterine endometrium, stimulating breast growth, relaxing the uterus, preventing follicle maturation and release, and supporting pregnancy maintenance.
Directions for Use
Take PROGESTERONE (NATURAL MICRONIZED) as prescribed by your doctor, consistently at the same time each day. Swallow the tablet whole with water; do not crush or chew
Storage
Store in a cool and dry place away from sunlight
INDICATIONS AND USAGE:

Threatened abortion or prevention of habitual abortions due to Luteal insufficiency.
Female infertility due to Luteal insufficiency.
Luteal phase support in ART procedures.

CONTRAINDICATIONS:

Allergy (hypersensitivity) to progesterone, progesterone-like drugs, or any of the inactive ingredients in the Tablet.
Suspected cases of pregnancy and nursing mothers.
Unexplained vaginal bleeding.
Recent case of miscarriage

PRECAUTIONS:

• The use of Cleargest should be restricted to the cases of Corpus Luteal Deficiency only.
• Cleargest is not known to be teratogenic; however, it should be administered only during the first trimester of pregnancy and through the oral route.
• While Cleargest is not known to be teratogenic, its administration during the 2nd and 3rd trimesters of pregnancy may lead to the development of Cholestatic jaundice of pregnancy or hepatocellular liver disease
• Cleargest is not indicated for the treatment of threatening premature labor.

ADVERSE REACTIONS:
While Cleargest is generally well-tolerated, individuals may experience side effects such as somnolence and dizziness. If these effects occur, consideration should be given to reducing the daily dose or adjusting the treatment schedule.
In cases of intermittent bleeding or shortening of the cycle, it is advisable to initiate treatment later in the cycle. For example, the treatment could commence on the 19th day rather than the 17th day.

DOSAGE AND ADMINISTRATION:

As directed by the Physician

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Follow the doctor’s prescription precisely when taking DOXYLAMINE+PYRIDOXINE+FOLIC ACID. Common side effects include mild and temporary sensations like dizziness, drowsiness, dry mouth, tiredness, and constipation. If any of these side effects persist or worsen, it is essential to promptly inform your doctor for further guidance.
Taking DOXYLAMINE+PYRIDOXINE+FOLIC ACID is not advisable for individuals allergic to any of its components. Before initiating this medication, notify your doctor if you have conditions such as asthma, glaucoma (elevated eye pressure), stomach ulcer, stomach or small intestine blockage, bladder blockage, or vitamin B12 deficiency. This medication is not recommended for use in children and breastfeeding mothers. Avoid consuming alcohol while on this medication, as it may heighten the risk of side effects. Due to potential drowsiness and dizziness, refrain from driving or operating heavy machinery if not fully alert.
Uses of CWTCG
Nausea and vomiting during pregnancy

Medicinal Benefits
DOXYLAMINE+PYRIDOXINE+FOLIC ACID, classified as an ‘anti-emetic,’ is primarily employed to address nausea (feeling sick) and vomiting (being sick) during pregnancy. This medication combines the benefits of Doxylamine, an antihistamine that blocks the natural chemical histamine, preventing nausea and vomiting; Pyridoxine, a form of vitamin B6, addressing deficiencies that may cause these symptoms by restoring B6 levels; and Folic acid, another vital form of vitamin B, providing essential nutrients crucial during pregnancy.

Directions for Use
For optimal effectiveness, take CWTCH before food, preferably 1 to 2 hours before a meal. Administer the medication by swallowing it whole with water; avoid crushing, breaking, or chewing it.
Storage
Store in a cool and dry place away from sunlight
Side Effects: Common side effects of DOXYLAMINE+PYRIDOXINE+FOLIC ACID may include:

• Drowsiness
• Dizziness
• Tiredness
• Dry mouth
• Constipation

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Glimitate M1 is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin SR is a Sustained-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.

Take Glimitate M1 as prescribed by your doctor. You are advised to take GLIMEPIRIDE+METFORMIN for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of GLIMEPIRIDE+METFORMIN do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to GLIMEPIRIDE+METFORMIN or any other medicines, please tell your doctor. GLIMEPIRIDE+METFORMIN is not recommended for children. Avoid breastfeeding while taking GLIMEPIRIDE+METFORMIN as it may be excreted in human milk.

If you are pregnant or planning for pregnancy, please inform your doctor before taking GLIMEPIRIDE+METFORMIN as it may harm the unborn baby. Avoid alcohol consumption with GLIMEPIRIDE+METFORMIN as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking GLIMEPIRIDE+METFORMIN. Take short, frequent meals and avoid prolonged fasting while taking GLIMEPIRIDE+METFORMIN.

Uses of Glimitate M1
In Type 2 diabetes mellitus
Medicinal Benefits
Glimitate M1 contains Glimepiride 1mg and Metformin 500mg used in the treatment of type 2 diabetes. Glimepiride stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin PR is a prolonged-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.

DOSAGE & ADMINISTRATION:
General
Dosage should be individualized based on both effectiveness and tolerance. The combination should be given once daily (daily) with meals and should be started at a low dose. The initial recommended dose is one tablet once daily with breakfast or the first main meal of the day and gradually titrated after assessing the adequacy of the therapeutic response.
Directions for Use
Take GLIMEPIRIDE+METFORMIN as advised by your doctor. Swallow it as a whole with a glass of water. Do not crush or break it.
Storage
Store in a cool and dry place away from sunlight

CONTRAINDICATIONS:
1. Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels 1.5 mg/dL [males], 1.4 mg/dL [females] or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and Septicaemia.
2. Congestive heart failure requiring pharmacologic treatment.
3. Known hypersensitivity to this product or any of its components.
4. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin.
5. Patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because the use of such products may result in acute alteration of renal function.

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